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KMID : 0371320020620020145
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Journal of the Korean Surgical Society
2002 Volume.62 No. 2 p.145 ~ p.149
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Radiofrequency Ablation of Hepatic Metastasis from Colorectal Cancer; EarlyExperience
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Min Byung-Soh
Rhee Kang-Young
Park Jea-Kun
Kim Nam-Kyu
Lee Jong-Tae
Min Jin-Sik
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Abstract
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Purpose: The aim of this study is to describe the safety and efficacy
of radiofrequency ablation (RFA) in the treatment of unresectable liver
metastasis from colorectal cancer. Methods: From January 1999 to
December 2000, we undertook 48 RFA procedures in 36 patients with
unresectable metastatic liver tumor from colorectal cancer. RFA was
performed either via celiotomy (n=23) or using a percutaneous approach
(n=25) under ultrasound guidance using a LeVeen needle electrode and a RF
2000 generator. Patients were followed with spiral computed tomographic
scans at 1 week after RFA. Results: RFA was performed in 15 patients
with synchronous hepatic metastasis and 21 with metachronous hepatic
metastasis. The mean tumor size was 3.1 ㎝ (range; 0.5∼7.2 ㎝). In 2
patients, complete ablation failed due to anatomic tumor location. Nine
patients (25%) exhibited post RFA complications (9 cases of fever, 8 of
abdominal pain, and 1 of hematoma) which showed spontaneous resolution and
there was no treatment-related death. At a mean follow up of 10.1 months, 12
patients (33.3%) had recurred in the liver and 3 (8.6%) at the RFA site,
while 16 (44.4%) remained clinically free of disease. Conclusion:
Although RFA is a relatively safe procedure in patients with unresectable
hepatic metastasis from colorectal cancer, the possible development of new
metastatic disease after RFA is currently a limitation in this form of
treatment. Further study on the efficacy of RFA versus other treatment
modalities is needed.
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